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RExO

laser therapyJoseph Health Group’s exosome product, RExO, is comprised of tiny extracellular vesicles derived from mesenchymal stem cells. They are 40-100 nanometers in size and contain lipids, messenger-RNA, micro-RNA, signaling cytokines, and proteins to help create a regenerative response to various treatment therapies. Exosomes have a variety of reported functions and some of their better-documented activities are associated with a form of immune regulation. Exosomes are anti-inflammatory, anti-fibrotic, cross the “blood-brain barrier,” have minimal risk of clumping, are easy to administer, contain nearly three times more growth factors compared to adult stem cells, and influence the growth of target cells.

Exosomes are primarily used in cell signaling and are found in all bodily fluids. Cells communicate with each other using cytokines. These are proteins that are excreted by one cell and tell another cell what to do. Think of an orchestra and how the conductor ensures all instruments produce beautiful music instead of noise. The conductor, in this case, is the exosome.

The use of exosomes also holds the promise of being more cost-effective from the point of view of storage, logistics, manufacturing, and delivery.

Why RExO?

  • Mesenchymal Stem Cells (MSCs) are known to play a vital role in the regeneration of injured tissue by homing in on injured or diseased cells and secreting bioactive factors, Bioactive factors secreted by MSCs stimulate resident stem cells that then construct new tissue. Exosomes have the potential to recapitulate this therapeutic function while avoiding issues associated with using whole stem cells.
  • Within regenerative medicine, exosome therapy is the latest treatment that is impressing doctors – many argue that exosomes may be more important than stem cells due to their unique ability to function as a “messenger” within the body, transferring information from cell to cell. Enhancing regenerative medicine therapy with exosomes is considered a superior and optimal therapy.
  • Due to their small size, exosomes are better able to avoid entrapment in filter organs and cross biological barriers than mesenchymal stem cells.
  • Due to their acellular nature, there is a low risk of adverse side effects such as neoplastic transformation
    or eliciting an immune response.

Potential Treatment Areas:

  • Aesthetics
  • Back Pain
  • Cartilage Damage
  • Nerve Injury
  • Degenerated Joints
  • Joint Dysfunction
  • Knee Injuries
  • Rotator Cuff Injury
  • Ligament Tears
  • Meniscus Damage
  • Muscle Tears
  • Tendon Tears


Regenerative Medicine Peoria | (309) 693-2225